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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH2
All Species:
22.42
Human Site:
S472
Identified Species:
35.24
UniProt:
Q8IWU9
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWU9
NP_775489.2
490
56057
S472
N
V
V
Q
D
L
R
S
D
L
N
T
V
C
D
Chimpanzee
Pan troglodytes
XP_522470
490
55999
S472
N
V
V
Q
D
L
R
S
D
L
N
T
V
C
D
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
S472
N
V
V
Q
D
L
R
S
D
L
N
T
V
C
D
Dog
Lupus familis
XP_538286
708
77776
G690
N
V
V
Q
D
L
R
G
D
L
N
T
V
C
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGV2
488
55899
S470
N
V
V
Q
D
L
R
S
D
L
N
T
V
C
D
Rat
Rattus norvegicus
Q8CGU9
485
55603
S467
N
V
V
Q
D
L
R
S
D
L
N
T
V
C
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
E427
V
V
N
E
L
R
H
E
L
D
L
V
G
D
A
Chicken
Gallus gallus
P70080
445
51121
E428
V
V
N
E
L
R
H
E
L
D
I
V
S
D
A
Frog
Xenopus laevis
Q92142
481
55388
H463
M
V
V
R
E
L
R
H
E
L
D
I
V
N
D
Zebra Danio
Brachydanio rerio
NP_999960
473
54279
Q455
N
C
G
S
R
S
T
Q
R
L
T
T
V
C
D
Tiger Blowfish
Takifugu rubipres
NP_001027849
486
55494
S468
N
V
V
Q
D
L
R
S
D
L
T
T
V
C
D
Fruit Fly
Dros. melanogaster
P17276
452
51642
N435
Q
I
S
N
L
M
D
N
I
N
S
E
F
Q
I
Honey Bee
Apis mellifera
XP_394674
508
57954
G466
A
V
V
S
E
L
R
G
D
L
C
I
V
S
N
Nematode Worm
Caenorhab. elegans
P90925
457
52111
D440
L
A
R
D
I
R
S
D
I
S
T
L
E
E
A
Sea Urchin
Strong. purpuratus
XP_784134
479
54807
D461
D
V
I
N
N
V
R
D
E
L
T
I
L
M
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
58.9
N.A.
93
93.6
N.A.
68.3
68.5
68.7
72.2
80
48.5
56.6
46.7
53.2
Protein Similarity:
100
99.5
99.1
63.7
N.A.
95.3
96.7
N.A.
79.8
80.8
83.2
83
88.5
66.1
70.8
65.5
69.5
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
6.6
6.6
46.6
40
93.3
0
46.6
0
20
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
13.3
13.3
73.3
40
93.3
26.6
60
0
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
20
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
7
0
0
54
0
% C
% Asp:
7
0
0
7
47
0
7
14
54
14
7
0
0
14
60
% D
% Glu:
0
0
0
14
14
0
0
14
14
0
0
7
7
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
7
0
0
0
0
14
0
0
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
14
7
0
0
0
0
0
0
0
% H
% Ile:
0
7
7
0
7
0
0
0
14
0
7
20
0
0
7
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
7
0
0
0
20
60
0
0
14
74
7
7
7
0
0
% L
% Met:
7
0
0
0
0
7
0
0
0
0
0
0
0
7
0
% M
% Asn:
54
0
14
14
7
0
0
7
0
7
40
0
0
7
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
7
0
0
47
0
0
0
7
0
0
0
0
0
7
7
% Q
% Arg:
0
0
7
7
7
20
67
0
7
0
0
0
0
0
0
% R
% Ser:
0
0
7
14
0
7
7
40
0
7
7
0
7
7
0
% S
% Thr:
0
0
0
0
0
0
7
0
0
0
27
54
0
0
0
% T
% Val:
14
80
60
0
0
7
0
0
0
0
0
14
67
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _